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1. Synthetic Biology and the Risks of Misuse

Author:
Gigi Gronvall
Publication Date:
07-2020
Content Type:
Journal Article
Journal:
Fletcher Security Review
Institution:
The Fletcher School, Tufts University
Abstract:
Synthetic biology is a relatively new scientific field that aims to make biology easier to engineer and, thus, more useful. It is already delivering on its enormous promise, yielding FDA-approved chimeric antigen receptor (CAR) T-cell cancer therapeutics, as well as non-medical products such as laboratory-produced fabrics, flavorings, adhesives, and detergents.[1][2] Despite such progress, however, the rapid growth and democratization of synthetic biology — almost all of which is taking place in the private sector — brings security challenges. Like all areas of the life sciences, it is “dual-use” and able to be exploited. To make misuse more limited and difficult to en‐ force, the United States will need to partner with other nations, international organizations, and international businesses to govern areas of the synthetic biology field...
Topic:
Science and Technology, Biology, and Medicine
Political Geography:
Global Focus and United States of America

2. US and Russia Can End Use of Weapons-Usable Uranium for Medical Uses

Author:
Miles A. Pomper
Publication Date:
02-2014
Content Type:
Working Paper
Institution:
James Martin Center for Nonproliferation Studies
Abstract:
A new report co-authored by CNS Senior Research Associate Miles Pomper recommends steps for the United States and Russia to cooperate in ending Russian use of highly enriched uranium (HEU) in medical isotope production, an important step in keeping this nuclear weapons material from terrorists. Great progress has been achieved in recent years in minimizing civilian use of HEU as part of the international efforts to reduce the nuclear terrorism threat. In particular, the leading global suppliers of the molybdenum-99 (Mo-99) isotope, which is widely used in medical diagnostics, are taking steps to reduce and, in the medium time frame, completely eliminate the use of HEU in the production of medical isotopes. Major new steps towards phasing out HEU use in medical isotopes production could be announced at the Nuclear Security Summit that will take place in The Hague on March 24-25, 2014. The Russian nuclear industry has set for itself an ambitious goal of becoming one of the three top global suppliers of Mo-99, used in 80 per cent of the medical procedures involving isotopes particularly as a diagnostic tool. Growing Russian production could help stabilize the global Mo-99 market, which faced severe shortages on several occasions in 2005-2013. According to some estimates, in 2010 during a six month period medical facilities around the world were unable to perform diagnostic procedures for several million people due to the shortage of Mo-99; the shortfall was estimated at 7 million doses. However, until recently, Russia had been bucking global trends by planning to use HEU fuels and targets rather than safer low enriched uranium (LEU) for much of this production. The ‘Ending HEU Use in Medical Isotope Production: Options for Russian-US Cooperation’ report co-authored by the Moscow-based Center for Energy for Energy and Security Studies (CENESS) analyses what can be done by Moscow and Washington to harmonize the Russian producers’ plans to win a share of the global market, while at the same time facilitating the Russian nuclear industry’s transition to new market requirements for producing Mo-99 without HEU.
Topic:
Diplomacy, Nuclear Weapons, Nuclear Power, Nonproliferation, and Medicine
Political Geography:
Russia, Europe, North America, and United States of America

3. Mind the Gap: Regimes & Strengthening Radiological Security

Author:
Miles A. Pomper
Publication Date:
08-2014
Content Type:
Working Paper
Institution:
James Martin Center for Nonproliferation Studies
Abstract:
According to a new paper from CNS Senior Research Associate Miles A. Pomper, inadequate liability and insurance regimes mean that users of high-risk radiological sources have insufficient incentive to protect those sources from terrorists or substitute less risky alternatives. Such sources are used in medicine, oil and gas exploration, and industry, among other fields, and can be used in “dirty bombs” or other forms of radiological terrorism. Since the 9/11 attacks, governments, including the United States, have taken it upon themselves to institute emergency measures to improve source security, often using public funds. However, these measures are less than optimal and are expected to take many more decades. Moreover, even the United States—the lead country in spending on these efforts—routinely sacrifices radiological security to other budget priorities. Pomper therefore recommends two potential options to improve liability and insurance regimes governing radiological sources in order to incentivize users to reduce the risk of radiological terrorism.
Topic:
Security, Terrorism, Budget, Radiological Weapons, and Medicine
Political Geography:
North America and United States of America